Proteins drive essential biological processes, yet their interactions remain a major challenge in life sciences and drug discovery. Our research deciphers protein-protein and protein-RNA interactions, with a focus on intrinsically disordered regions (IDRs) and their roles in gene expression, autoimmunity, infection and cancer. By integrating library technologies and medicinal chemistry, we develop precision binders to visualize and modulate these interactions. Thereby we shed light on disease mechanisms and open new paths for therapeutic intervention.